WHAT SHOULD I KNOW ABOUT MEDICAL CANNABIS?
The cannabis plant belongs to the family Cannabaceae, genus Cannabis.
Cannabis cultivars can be classified in different chemotypes, generally depending on the relative amounts of THC and CBD (as percentage of weight) contained in the dried flowers.9 Cannabis chemotypes are:
THC-rich cannabis cultivars with little amounts of CBD (e.g. THC:CBD ratio 20:1)
Chemotype 2: cannabis cultivars containing a similar ratio of THC and CBD (ratio THC:CBD 1:1)
cannabis cultivars rich in CBD and small amounts of THC (e.g. ratio of THC:CBD 1:20)
The endocannabinoid system (ECS) is a lipid signaling system that serves important regulatory functions in the whole organism favoring homeostasis.10, 21 This system modulates many physiological processes including the regulation of neurotransmission, as well as endocrine and paracrine actions (see figure below):
Bone development and density
The main components of this cellular communication system are:
1. Cannabinoid receptors
(endogenous ligands of cannabinoid receptors, derived from arachidonic acid)
N-archidonoylethanolamide, or “anandamide” (AEA), named after the Sanskrit term “Ananda”, which
means “internal bliss”.
3. Enzymes responsible for endocannabinoid synthesis
Phospholipase D (NAPE-PLD) which produces anandamide and other fatty acid amides
such as OEA or PEA.
Diacylglycerol lipase (DAGL) which synthesizes
4. Enzymes responsible for endocannabinoid deactivation
Fatty acid amido-hydrolase (FAAH) which hydrolyzes AEA and related fatty-acid ethanolamides (OEA and PEA)
Monoacylglycerol lipase (MAGL), which degrades